Making big cells: one size does not fit all.
نویسنده
چکیده
During cell division, the genome is fully duplicated and then segregated to two daughter cells. In some tissues, however, cells repeatedly duplicate their genome and grow without dividing. This process results in large cells with many copies of their genome, a state known as polyploidy. In polyploid cells of the fruit fly Drosophila, DNA replication is not complete, which results in a relatively lower DNA copy number of specific genomic loci. In PNAS, Sher et al. show that in two different polyploid cell types of mice the entire genome is fully duplicated, unlike in Drosophila, and that this organismal difference may be explained by different levels of expression of the genes required for DNA replication (1). This report from Sher et al. reveals how these variant polyploid cell cycles can differ among organisms and tissues, but also uncovers many key similarities between flies and mammals that provide clues to the regulation of these enigmatic cell cycles.
منابع مشابه
Does One Size Fit All? The Impact of Liquidity Requirements on Bank\'s Insolvency: Evidence from Iranian Listed Banks
According to the Basel III regulatory framework, uniform minimum liquidity requirements have been imposed on all types of banks. Using an agent-based model of a banking system, we investigate the effects of liquidity requirements on banks' insolvency under two policy experiments in one of which the minimum liquidity requirements are applied uniformly and in the other differentially across banks...
متن کاملBig Data Quality: From Content to Context
Over the last 20 years, and particularly with the advent of Big Data and analytics, the research area around Data and Information Quality (DIQ) is still a fast growing research area. There are many views and streams in DIQ research, generally aiming at improving the effectiveness of decision making in organizations. Although there are a lot of researches aimed at clarifying the role of BIG data...
متن کاملBig Data Analytics and Now-casting: A Comprehensive Model for Eventuality of Forecasting and Predictive Policies of Policy-making Institutions
The ability of now-casting and eventuality is the most crucial and vital achievement of big data analytics in the area of policy-making. To recognize the trends and to render a real image of the current condition and alarming immediate indicators, the significance and the specific positions of big data in policy-making are undeniable. Moreover, the requirement for policy-making institutions to ...
متن کاملGhrelin Does not Alter Aortic Intima-Media Thickness and Adipose Tissue Characteristics in Control and Obese Mice
Objective(s): Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice. Materials and Methods:This study was conducted on 24 male C...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 110 24 شماره
صفحات -
تاریخ انتشار 2013